Enough time had passed since the patient’s previous colonoscopy that she met the criteria to undergo another, said Dr. Steven Itzkowitz, a gastroenterologist at the Icahn School of Medicine at Mount Sinai in New York.
She was in “reasonably good health,” and the risks of the procedure — bleeding, reaction to anesthesia, perforation of her colon — were fairly low. But she was 85. And she would need to briefly discontinue the blood thinners she took because of the cardiac stents keeping her arteries open; doing so could increase the risks.
Had Dr. Itzkowitz and his patient faced this decision five years ago, he might have scheduled the screening “without even thinking about it,” he said. But recent research has shown again that the benefits of a repeat colonoscopy are slim after age 75.
Now, he said, “I’m saying to myself, ‘What are we accomplishing here?’”
He’s not the only doctor — or patient — having second thoughts. The risks and benefits of common screenings, procedures and drugs add up differently at advanced ages, and research continues to point out fresh examples of some that may become unnecessary.
Recently, investigators have taken on questions about common skin lesions that probably don’t need to be removed, a widely used thyroid medication that many older patients can safely discontinue, and colonoscopies that reduce colon-cancer mortality so slightly that the risks may outweigh the benefits.
Ugly but Probably Harmless
The reddened or rough patches on the skin are called, in doctorspeak, actinic keratoses. Because they result from long-term sun exposure, they usually appear on faces, scalps, forearms and the backs of hands.
Such lesions appear most commonly on older patients. One large study of traditional Medicare beneficiaries found that over a five-year period, almost 30 percent were diagnosed with an actinic keratosis. Then what?
“The vast majority of the time, they’re removed,” said Dr. Allison Billi, a dermatologist at the University of Michigan and an author of a recent commentary on the topic in JAMA Internal Medicine. That typically involves cryosurgery (freezing with liquid nitrogen), topical creams or laser therapy.
The rationale: The patches could become cancerous. But “for the average patient with no history of skin cancer, there is less than a 1 in 1,000 chance of it progressing to skin cancer,” Dr. Billi said, citing a 2013 meta-analysis. The lesions are far more likely to disappear on their own.
“The treatment may be more burdensome than the condition itself,” she added. Removal “is actually extremely painful, both during and after.” It can cause swelling, irritation and lasting discoloration.
Besides, an actinic keratosis will probably reappear, or new ones will emerge. “This is a chronic condition,” Dr. Billi said.
She has proposed active surveillance, instead: Primary care doctors could observe the lesions annually for warning signs like bleeding, pain or rapid growth, which might warrant removal. But “in many cases, it’s not necessary,” she said. “We don’t always need to do everything we can do.”
She does recommend using sunscreen, however.
Questionable Treatment
Patients take levothyroxine, one of the world’s most frequently prescribed drugs, when their thyroid glands can’t produce sufficient thyroid hormone.
With this condition, called hypothyroidism, “people gain weight. They have less energy. Their hair and skin are dry,” explained Dr. Jacobijn Gussekloo, a primary care doctor and researcher at Leiden University Medical Center in the Netherlands. “Everything slows down.”
Doctors also increasingly prescribe it for a borderline condition called subclinical hypothyroidism, which usually causes no symptoms but can progress to hypothyroidism.
Most patients take the drug for life — but do they have to? Dr. Gussekloo’s team has found that in many older adults with subclinical hypothyroidism, hormone levels normalize on their own.
The researchers have also reported that among older people with the condition, levothyroxine had no effect on symptoms and “no apparent benefit.”
Like any drug, it can also cause harms. It may interact with other medications that older patients typically take. Moreover, “it requires frequent lab tests and follow-ups, more visits and expense,” said Dr. Maria Papaleontiou, an endocrinologist at the University of Michigan and an author of an editorial in JAMA accompanying the latest Dutch study.
“In high doses, it can cause hyperthyroidism, which can lead to cardiac arrhythmias and bone loss,” she added. Patients taking it also have to adjust their diets and meal schedules.
To determine whether some patients could stop taking levothyroxine, the Dutch researchers devised a protocol that gradually reduced doses over 30 weeks, with ongoing lab testing and consultations with doctors.
After a year, a quarter of the 370 participants, all over 60, had discontinued the drug while maintaining healthy thyroid function. Most had been on lower doses to begin with.
Patients shouldn’t stop levothyroxine on their own, Dr. Papaleontiou cautioned. Discontinuation requires tapering off gradually, with testing and monitoring. Some patients will always need the drug.
But it appears that “a select group of adults over 60 may not require this treatment lifelong,” Dr. Papaleontiou said.
A Screening With Risks
The question of when older patients can safely stop screening for colon cancer has prompted years of debate. The influential United States Preventive Services Task Force gives the screening a lukewarm C rating after age 76, calling the benefit “small.”
Yet almost 60 percent of older patients who have had previous colonoscopies and face limited life expectancies (less than five years) are advised to undergo another screening, a 2023 study found.
As a gastroenterologist at the University of California, San Diego, Dr. Samir Gupta regularly encounters this issue with older patients. “I know they really have a low risk of colon cancer, and I’m putting them through more risk,” he said.
The risk of complications following a colonoscopy rise with age. One recent study found that nearly 7 percent of patients over 75 had a hospitalization or emergency-room visit within a month of the procedure.
Is it worth it? Dr. Gupta is the lead author of a new study of almost 92,000 Veterans Affairs patients over 75 who had previous colonoscopies. In about 28 percent, the procedure had found an adenoma, a type of polyp that can become cancerous. Though only a small fraction do, gastroenterologists generally remove them.
The researchers found that after 10 years, veterans with a previous adenoma were more likely to develop colon cancer than those without one, though the rate was extremely low in both groups.
But just .5 percent — yes, one-half of 1 percent — of those with a previous adenoma died of colon cancer, compared with .4 percent of those without one: “a tiny difference,” Dr. Gupta said.
Both groups were dwarfed by the number of veterans — almost half — who died within the decade of other causes.
“Even if the procedure goes well, you’ll either find nothing or you’ll find something that’s not going to have real impact on your longevity,” said Dr. Itzkowitz, an author of an editorial published alongside the study.
Yet he has found that many patients who have had polyps removed want to continue colonoscopies.
It is hard to shift established medical norms. Efforts to “deprescribe” drugs can meet with opposition from both patients and health care professionals.
Many older women continue having mammograms past the point of documented benefit, and older men often undergo prostate cancer screening beyond the recommended age.
Colonoscopies are less pleasant, so perhaps older patients will be glad to forgo them. “Even with polyps, the chance of dying from colon cancer is so low compared to everything else that can get you,” Dr. Itzkowitz said.
So he told his 85-year-old patient that she could skip another colonoscopy. She seemed pleased.
